Overview
SS-31 is a cell-permeable peptide consisting of alternating aromatic and basic amino acids (D-Arg-Dmt-Lys-Phe-NH2). In laboratory research models, its unique molecular structure allows it to easily penetrate cellular boundaries independent of membrane potential and localize exclusively within the inner mitochondrial membrane. By directly interacting with cardiolipin, SS-31 alters foundational lipid-protein interactions to restore structural mitochondrial cristae architecture during cellular aging or environmental insult.
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